Eruptive pseudoangiomatosis is rare, benign, self-limiting skin disease characterized by sudden onset of red papules in adults and medical workers exposed to patients with the disease.


Causes

Eruptive pseudoangiomatosis is caused by Echo virus 25 and 32, as well as Epstein-Barr virus.


Signs and Symptoms

2 to 4mm red blanching papules suddenly occur, resembling hemangioma, with 1 to 2mm pale halos. About 10 eruptions, sometimes more eruptions, occur mainly in the face, limbs, as well as trunk. Skin lesions subside in about 10 days in children, but persist for longer in adults. Children patients usually develop systemic symptoms of viral infection, such as general malaise, fever, headache, sore throat, muscle aches, and loss of appetite. Adults often have no symptoms.


Histopathology

Vasodilation in the superficial dermis and swollen vascular endothelial cells protruding into the lumen can be seen, but vascular proliferation is absent.


Diagnosis

On the basis of the clinical and histological findings, a diagnosis can be provided.


Treatment

Eruptive pseudoangiomatosis is self-limiting and can relapse. Special treatment is absent. Symptomatic treatment can be applied when systemic symptoms occur.