Dukes disease, also known as parascarlatina, fourth disease, or Filatov-Dukes disease, is a eruptive disease.


Dukes disease is an eruptive disease that may be caused by Coxsackie and Echovirus, but there is no exact evidence of these viruses currently. It has also been suggested that this disease has some similarities with staphylococcal epidermal necrolysis.

Signs and Symptoms

Dukes disease occurs mainly in the spring and summer, more common in children aged 3 to 4 years old. Mild systemic symptoms are present at onset, and skin lesions are small, rosy, slightly elevated spots, initially in folds such as neck, armpits, and groins, spreading rapidly to the whole body in several hours, resembling scarlet fever-like rash, with or without upper respiratory tract catarrh, superficial lymph node enlargement. Skin lesions spontaneously subside 4 - 5 days after onset, with or without pityroid desquamation. Peripheral blood is normal or lymphocytes are increased.


On the basis of clinical presentations such as mild systemic symptoms, small rosy pimples, and short duration, a diagnosis can be provided.


Symptomatic treatment is appropriate.