Corynebacterium jeikeium infection: causes, diseases, and treatment

Corynebacterium jeikeium can cause various infections mostly in the immunocompromised patients and merely in immunocompetent patients.


Causes

Corynebacterium jeikeium is an obligate aerobic, Gram- positive bacterium colonizing on the skin of hospital workers and hospitalized patients, and the bacteria count in the armpit and perineum is the most. In hospitalized patients, the colonization of the bacteria is more serious. Patients with neutropenia, indwelling catheters or prostheses, or valve defects have the highest risk of sepsis or endocarditis. Most cases are associated with immunosuppression, skin disruption by indwelling medical devices, or trauma.

Corynebacterium jeikeium is only pathogenic for humans, is distributed in soil and water and is part of normal human skin flora, and is a significant opportunistic pathogen primarily in the immunocompromised host.


Diseases

Corynebacterium jeikeium can cause various infections, such as bloodstream infection, diphtheroid endocarditis of prosthetic valve, skin and wound infections, catheter-related infections, enteritis, meningitis, osteomyelitis, peritonitis, pneumonia, prosthetic joint infections, pyelonephritis, and liver abscess.


Treatment

Studies have shown that the bacterium is resistant to a variety of antibiotics, including penicillin, trimethoprim-sulfamethoxazole, fosfomycin, macrolides, and mupirocin, and is insensitive to ciprofloxacin, ofloxacin, doxycycline, tetracycline, and fusidic acid. Most strains are sensitive to rifampicin. Almost all strains are sensitive to glycopeptide antibiotics such as teicoplanin and vancomycin.